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Ivectin


Ivectin® 1%

Ivermectin

Injectable solution

Each ml contains 10 mg Ivermectin

Pharmacology:

As an avermectin anthelmintic, ivermectin enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA, ivermectin causes paralysis of the parasite and eventual death. As liver flukes and tapeworms do not use GABA as a peripheral neurotransmitter, ivermectin is ineffective against these parasites.

Pharmacokinetics:

There is great bioavailability after SC administration and distribution to most tissues, but does not readily penetrate into the CSF, thereby minimizing its toxicity. Collie-breed dogs apparently allow more ivermectin into the CNS than other breeds/species.

Ivermectin has a long terminal half-life in most species. Less than 5% of the drug is excreted in the urine.

Indications:

Ivermectin is approved for use in control of roundworms, strongyles, pinworms, ascarids, hairworm, large-mouth stomach worms, threadworms, bots, lungworms, summer sores, eye worm, lice, mange mites and heartworm as an anthelmintic.

Administration and dosage:

Cattle, Camel, sheep and horses: 0.5 ml per 25 kg b.w SC in shoulder area

Dogs and Cats: 200 μg/kg SC. For heartworm prophylaxis administer ivectin 6 μg/kg b.w SC once monthly

Contraindications and warnings:

Ivermectin must not be used in foals less than 4 months old and puppies less than 6 weeks old.

This drug formulated to be administered SC, do not give it IM or IV.

Use in Collie-breeds with caution and less than routine dose. Observe this breed for at least 8 hours after administration.

Dispose of unused products and containers by incineration or in approved-landfills. Ivermectin may adversely affect fish or other waterborne organism if disposed in water.

Withdrawal time:

Meat: 35 days

Milk: 28 days

Storage:

Store at room temperature and protect from light and freezing

Keep out of sight and reach of children

Presentation:

50 ml vials

 

 

Product Licence Number from IVO: 77-26-A.P

 

For Veterinary Use Only

 
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Manufactured by RAZAK labs Co.

10th km of Karaj Special road

Tehran-Iran

 

All rights reserved by Razak Laboratory Co.